4 edition of Hematopoietic Cytokine Receptor Signaling (Molecular Biology Intelligence Unit) found in the catalog.
Hematopoietic Cytokine Receptor Signaling (Molecular Biology Intelligence Unit)
by Ray Langley
Written in English
|The Physical Object|
|Number of Pages||229|
Although some receptor subfamilies are dimers of a single unique receptor subunit, such as the erythropoietin receptor, most subfamilies consist of a multisubunit complex with a unique and specific ligand-binding subunit and a common shared signaling subunit. Keywords: JAK-STAT, JAK2 VF, myeloproliferative disorders, hematopoietic stem cells, mouse models Janus kinases (JAKs) are non-receptor tyrosine kinases essential for activation of signaling mediated by cytokine receptors that lack catalytic activity, including receptors for erythropoietin, thrombopoietin, most interleukins and inter-feron.
Decades of research in hematopoietic cell biology, and indeed entire laboratories, have focused on the structure and function of cytokine receptors since cytokine signaling is responsible for the majority of the decision-making in blood cell production (how much and . Chimeric receptors were constructed by replacing the cytoplasmic tail of constitutively active variants of the EPO receptor with tails of diverse cytokine receptors. Receptors linked to granulocyte or platelet production supported complete erythroid development in vitro and in vivo, as did the growth hormone receptor, a nonhematopoietic by:
Cytokines are the principal regulators of cell proliferation and differentiation of hematopoietic cells and these responses are initiated through activation of hematopoietic cytokine receptors. Although the receptor intracellular domains lack any kinase domains, activation of cytokine receptors lead to rapid induction of tyrosine by: T1 - Signaling through the hematopoietic cytokine receptors. AU - Ihle, James N. AU - Witthuhn, Bruce A. AU - Quelle, Frederick W. AU - Yamamoto, Koh. AU - Silvennoinen, Olli. PY - /1/1. Y1 - /1/1. N2 - Hematopoiesis is regulated through the interaction of a variety of growth factors with specific receptors of the cytokine receptor Cited by:
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Buy Hematopoietic Cytokine Receptor Signaling (Molecular Biology Intelligence Unit) on FREE SHIPPING on qualified orders Hematopoietic Cytokine Receptor Signaling (Molecular Biology Intelligence Unit): Silvennoinen, Olli, Ihle, James N.: : Books.
Hematopoiesis is the cumulative result of intricately regulated signaling pathways that are mediated by cytokines and their receptors. The Jak/Stat signaling pathway represents a novel pathway that is primarily utilized by the cytokine receptor : J.
Ihle. ISBN: X OCLC Number: Description: pages: illustrations ; 26 cm. Contents: 1. Introduction: Cellular Networks for Cytokines Biology and Characterization of Hematopoietic Cytokines Characterization of Cytokine Receptors: Structure and Signaling Domains Regulation of Cytokine Receptor Signal.
Recent studies conducted over the past 10–15 years have revealed that hematopoietic cytokine receptor signaling is largely mediated by a family of tyrosine kinases termed Janus kinases (JAKs Cited by: The hematopoietic cytokine/receptor system, which funnels its signals through conserved JAK/STAT intracellular pathways, is arguably the key regulator of the developmental fates and functional roles of blood cell types.
As such, this system is critical in helping marshall and shape effective immune responses to pathogen attack. The three hematopoietic cytokines signaling through tyrosine kinase receptors, stem cell factor (SCF), Flt3 ligand (FL), and colony stimulating factor-1 (CSF-1), are members of a family of.
tion enhanced T cell receptor signaling and cytokine secretion in a T-cell-intrinsic manner. In response to chronic lymphocytic choriomeningitis virus (LCMV) infection or tumor challenge, viral clearance and tumor growth inhibition were enhanced in mice, accompanied by an increase in effector CD8 T cell function.
Co-blockade of PD-L1 further. Cytokine receptors and hematopoietic differentiation. A role for G-CSF receptor signaling in the regulation of hematopoietic cell function but not lineage commitment or Cited by: Zhao et al.
reveal that, during an infection, hematopoietic stem and progenitor cells respond directly to Toll-like receptor signaling to produce IL-6 and other cytokines in order to Cited by: signaling system of the cytokine receptor superfarrtily.
In initial studies of cytokine receptor signals, it was thought that the unique structural features and the rather limited expression in hematopoietic cells of the cytokine receptor superfamily may account for the cytokine or hematopoietic cell specific signaling me The results presented in this report describe the cytokine receptor profile on highly enriched populations of hematopoietic stem and progenitor cells as summarized in Fig 2.
Analyses of cytokine receptors on both primitive and mature HSC populations revealed similar by: The class II cytokine receptor family includes the interferon receptors, IL receptor, and number of more recently discovered cytokine receptors for IL, IL, IL, IL, IL, and IL This chapter will review the structure, activation mechanism, and signaling of cytokine receptors.
These data implicate Lnk as playing an important role in hematopoiesis and in the regulation of growth factor and cytokine receptor–mediated signaling. Introduction The growth, differentiation, and function of immune and hematopoietic cells are controlled by the coordinated actions of multiple cytokines (1).Cited by: Signaling Through the Hematopoietic Cytokine Receptors.
Annual Review of Immunology Vol. (Volume publication date April ) high and sustained inhibitory receptor expression, Read More. Full Text HTML; Download PDF; Comparison of the signaling pathways that underpin calreticulin (CRT) exposure in response to Cited by: The cytokine receptor superfamily is characterized by structural motifs in the exoplasmic domain and by the absence of catalytic activity in the cytosolic segment.
Activated by ligand-triggered multimerization, these receptors in turn activate a number of cytosolic signal transduction proteins, including protein tyrosine kinases and phosphatases, and affect an array of cellular functions that Cited by: Cytokines are small proteins that bind to the extracellular domains of transmembrane receptors to activate signaling pathways inside the cell.
They often act by dimerizing their receptors, and changes in dimer orientation of the extracellular domains can change the signaling output. Mohan et al. systematically explored this tuning effect by designing a series of dimer ligands for the Cited by: 5. Tyrosine Kinase Receptors.
The three hematopoietic cytokines signaling through tyrosine kinase receptors, stem cell factor (SCF), Flt3 ligand (FL) and colony stimulating factor-1 (CSF-1), are members of a family of homodimeric cytokines that share some sequence and structural similarity.
The three hematopoietic cytokines signaling through tyrosine kinase receptors, stem cell factor (SCF), Flt3 ligand (FL), and colony stimulating factor-1 (CSF-1), are members of a family of homodimeric cytokines that share some sequence and structural similarity.
Cytokines and cytokine receptors regulating cell survival, proliferation, and Cited by: 4. Through SCF binding, c-Kit is a key controlling receptor in a number of cell types including HSCs and hematopoietic progenitors, mast cells, melanocytes, and germ cells. The growth and survival of the stem cells for these cell types are severely affected by mutations in the gene loci for c-Kit (Kit W) or SCF (sl) (15).Cited by:.
CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): The adaptor protein Lnk, and the closely related proteins APS and SH2B, form a subfamily of SH2 domain-containing proteins implicated in growth factor, cytokine, and immunoreceptor signaling.
To elucidate the physiological function of Lnk, we derived Lnk-deficient mice.The stage is now set to link distinct forms of cytokine receptor assembled structures to specific forms of cytokine receptor signaling and function.
Armed with this knowledge it may be possible to map distinct cytokine receptor signaling pathways from the cell surface to the cell nucleus which may themselves become new therapeutic targets Cited by: Cytokine receptor expression is the result, rather than the cause, of lineage commitment; it allows specific cytokines to selectively rescue and amplify progenitors of a particular lineage according to physiological need.
The unique outcome of cytokine receptor signaling is a result of the unique cellular environment in committed by: